New Features in DataSpaceR
New features have been added to DataSpaceR that allow for adding LANL metadata to mAb data pulled with the API, and assistance for users who what to apply standard virus names to data not already found in DataSpace. We are also providing a cheat sheet to help users use the DataSpaceR API quickly and efficiently. Read more
New mAb magnitude-breadth reports
New data uploads - November 2020
Data has been uploaded for 1 clinical trial and 4 antibody screening studies including: Click on the study page links below for Protocol Team reports, data summaries, and more details about the studies. Name & Description Data Added Type PI Strategy CAVD 446 (Protocol # MCA-835) is a Phase 1, open label, dose-escalation study of the safety, pharmacokinetics and antiretroviral activity of 3BNC117 monoclonal antibody in HIV-infected and HIV-uninfected volunteers PK… Read more
Publication data now available!
DataSpace now provides analysis datasets on the publication pages in Learn. The Learn section offers detailed information and metadata regarding data found in DataSpace. The Publications section in Learn is a compilation of CAVD and HVTN manuscripts (plus a few other publications for related trials like RV144). Each publication has its own publication page. The data used for these publications can now be posted to and downloaded from the publication pages. In… Read more
New data uploads - June 2020
Data has been uploaded for 3 pre-clinical studies including: Click on the study page links below for Protocol Team reports, data summaries, and more details about the studies. Name & Description Data Added Type PI Strategy CAVD 278 (CAVIMC-040) is an immunogenicity study to define the epitopes recognized by a panel of anti-gp41 monoclonal antibodies that mediate ADCC NAB MAB Antibody Screening George Lewis Prophylactic neutralizing Ab CAVD 569 is an immunogenicity… Read more
Specimen repository links
The HVTN and several other clinical trial networks have collaborated on a shared specimen repository tracking system in order to make the larger body of specimens collected for HIV research available to investigators. The specimens stored at the repositories were initially collected for specific studies that have concluded, have been approved for use by network leadership and are now available to investigators conducting new research. Links to the specimen… Read more
New data uploads - April 2020
Data has been uploaded for 3 studies including: Click on the study page links below for Protocol Team reports, data summaries, and more details about the studies. Name & Description Data Added Type PI Strategy CAVD 465 is a non-human primate challenge study to evaluate and compare the immunogenicity of priming with adenoviral vectors encoding FIV Gag, SIV Gag, HIV Env or a control antigen (RSV-F) and boosting with VLPs containing FIV Gag and HIV Env (FIVHenv) or SIV Gag and… Read more
Virus metadata updates
We've updated the Learn about - Assay pages for the neutralizing antibody assays (NAb and NAb MAb) to add more metadata about viruses tested in CAVD and HVTN studies. Viruses listed on the Antigens tab are displayed with a standardized full name and other names used for the virus in publications and databases. The full name includes the virus backbone in brackets, followed by the host cell associated with the virus. The full name will also include the virus type in… Read more
What's in store for the DataSpace
Here are some of the new features you'll see in 2020: And of course, we'll also be loading more CAVD and HVTN study data, including ADCC data integrated across studies. Read more
More assay data now available!
There have been over 50 different assays performed in CAVD and HVTN studies. Currently, the DataSpace provides standardized assay data, integrated across studies, for the most commonly performed assays, i.e. BAMA, ICS, NAb, PK MAb, and ELISpot. In order to provide data for additional assays that have not yet been standardized, or are not able to be standardized, we have upgraded the DataSpace to enable us to post individual, study-specific datasets to the study pages.… Read more
Going to the CAVD Annual Meeting?
We'll be at the CAVD Annual Meeting in Seattle: Stop by our demo station on the lower level. We've added data for more studies and more assay types, including pharmacokinetics data for monoclonal antibodies, Come see what's new! Read more
New data uploads - November 2019
Data has been uploaded for 4 studies including: Click on the study page links below for Protocol Team reports, data summaries, and more details about the studies. Name & Description Data Added Type PI Strategy CAVD 432 is a non-human primate study of protein and adjuvant regimens BAMA, NAB Pre-Clinical NHP Bali Pulendran Protein and peptide vaccines CAVD 514 (Protocol MCA-0885) is a Phase 1 open-label, dose escalation clinical trial to evaluate the safety,… Read more