New data uploads - November 2019

More study data available!

Data has been uploaded for 4 studies including:

  • Clinical trials:
    • CAVD 514 (Nussenzweig Ph I) evaluates increasing doses of 10-1074 (3, 10, 30 mg/kg) in HIV infected and uninfected subjects
    • CAVD 583 (Nussenzweig Ph I) evaluates a combination of 3BNC117 and 10-1074 given in single (10 mg/kg) or multiple timepoint (3 and 10 mg/kg) regimens
    • HVTN 505 (Hammer Ph IIb) evaluates a VRC-HIVDNA016-00-VP (DNA) and VRCHIVADV014-00-VP (rAd5) combination regimen
  • Pre-clinical studies:
    • CAVD 432 (Pulendran ​​NHP) study compares envelope-specific antibody responses across groups receiving different adjuvants combined with HIV-1 gp140 trimer (1086C).

Click on the study page links below for Protocol Team reports, data summaries, and more details about the studies.

Data was uploaded for the following studies:

Name & Description

Data Added

Type

PI

Strategy

CAVD 432 is a non-human primate study of protein and adjuvant regimens

BAMA, NAB

Pre-Clinical NHP

Bali Pulendran

Protein and peptide vaccines

CAVD 514 (Protocol MCA-0885) is a Phase 1 open-label, dose escalation clinical trial to evaluate the safety, pharmacokinetics and the antiretroviral effects of the highly neutralizing anti-HIV-1 monoclonal antibody 10-1074 in HIV-infected and HIV-uninfected individuals

PK MAB

Phase I

Michel Nussenzweig

Prophylactic neutralizing Ab

CAVD 583 (Protocol YCO-899) is a Phase 1 clinical trial evaluating safety and pharmacokinetics of the highly neutralizing anti-HIV-1 monoclonal antibodies 3BNC117 and 10-1074 in healthy HIV-uninfected participants

PK MAB

Phase I

Michel Nussenzweig

Prophylactic neutralizing Ab

HVTN 505 is a Phase IIb clinical trial to evaluate the safety and immunogenicity of VRC-HIVDNA016-00-VP (DNA) and VRCHIVADV014-00-VP (rAd5)

Non-integrated datasets: ADCP, Fc Array, supplemental demographics

Previously posted: BAMA, NAB, ICS

Phase IIb

Scott Hammer

Combo: DNA and vector vaccines

Written by CAVD DataSpace Team on November 11, 2019

Tags: data, updates - Category: updates

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