Data

New data uploads - November 2020

Data has been uploaded for 1 clinical trial and 4 antibody screening studies including: Click on the study page links below for Protocol Team reports, data summaries, and more details about the studies. Name & Description Data Added Type PI Strategy CAVD 446 (Protocol # MCA-835) is a Phase 1, open label, dose-escalation study of the safety, pharmacokinetics and antiretroviral activity of 3BNC117 monoclonal antibody in HIV-infected and HIV-uninfected volunteers PK… Read more

Written by CAVD DataSpace Team on November 23, 2020

Tags: data, updates - Category: updates


New data uploads - June 2020

Data has been uploaded for 3 pre-clinical studies including: Click on the study page links below for Protocol Team reports, data summaries, and more details about the studies. Name & Description Data Added Type PI Strategy CAVD 278 (CAVIMC-040) is an immunogenicity study to define the epitopes recognized by a panel of anti-gp41 monoclonal antibodies that mediate ADCC NAB MAB Antibody Screening George Lewis Prophylactic neutralizing Ab CAVD 569 is an immunogenicity… Read more

Written by CAVD DataSpace Team on June 27, 2020

Tags: data, updates - Category: updates


New data uploads - April 2020

Data has been uploaded for 3 studies including: Click on the study page links below for Protocol Team reports, data summaries, and more details about the studies. Name & Description Data Added Type PI Strategy CAVD 465 is a non-human primate challenge study to evaluate and compare the immunogenicity of priming with adenoviral vectors encoding FIV Gag, SIV Gag, HIV Env or a control antigen (RSV-F) and boosting with VLPs containing FIV Gag and HIV Env (FIVHenv) or SIV Gag and… Read more

Written by CAVD DataSpace Team on April 24, 2020

Tags: updates, data - Category: updates


What's in store for the DataSpace

Here are some of the new features you'll see in 2020: And of course, we'll also be loading more CAVD and HVTN study data, including ADCC data integrated across studies. Read more

Written by CAVD DataSpace Team on January 15, 2020

Tags: updates, features, data - Category: announcements, updates


More assay data now available!

There have been over 50 different assays performed in CAVD and HVTN studies. Currently, the DataSpace provides standardized assay data, integrated across studies, for the most commonly performed assays, i.e. BAMA, ICS, NAb, PK MAb, and ELISpot. In order to provide data for additional assays that have not yet been standardized, or are not able to be standardized, we have upgraded the DataSpace to enable us to post individual, study-specific datasets to the study pages.… Read more

Written by CAVD DataSpace Team on November 27, 2019

Tags: data, features, updates - Category: announcements, updates


New data uploads - November 2019

Data has been uploaded for 4 studies including: Click on the study page links below for Protocol Team reports, data summaries, and more details about the studies. Name & Description Data Added Type PI Strategy CAVD 432 is a non-human primate study of protein and adjuvant regimens BAMA, NAB Pre-Clinical NHP Bali Pulendran Protein and peptide vaccines CAVD 514 (Protocol MCA-0885) is a Phase 1 open-label, dose escalation clinical trial to evaluate the safety,… Read more

Written by CAVD DataSpace Team on November 11, 2019

Tags: data, updates - Category: updates


PK mAb data now available!

The CAVD and HVTN have seen an increased emphasis on passive immunization studies where participants receive a monoclonal antibody (mAb) as part of a prophylactic or treatment regimen. The PK data from these studies is important for evaluating and further characterizing those mAbs known to be broadly neutralizing (bNAbs), determining the appropriate dose levels required to maintain optimal concentration levels of mAbs in the blood, and identifying potential… Read more

Written by CAVD DataSpace Team on November 4, 2019

Tags: data, features, updates - Category: announcements, updates


New data uploads - May 2019

Data has been uploaded for 5 studies including: Click on the study page links below for Protocol Team reports, data summaries, and more details about the studies. Name & Description Data Added Type PI Strategy HVTN 097 is a Phase Ib clinical trial to evaluate the safety and immunogenicity of prime/boost regimens using combinations of ALVAC-HIV (vCP1521), AIDSVAX B/E, and bivalent subtype C gp120/MF59. BAMA, ICS, NAB Phase Ib Glenda Gray Combo: DNA, protein & vector… Read more

Written by CAVD DataSpace Team on May 31, 2019

Tags: data, updates - Category: updates


New data uploads - January 2019

Data has been uploaded for 3 studies including: Click on the study page links below for Protocol Team reports, data summaries, and more details about the studies. Name & Description Data Added Type PI Strategy CAVD 426 is an antibody screening study to isolate and characterize monoclonal antibodies from RV144, RV305, and RV306 human clinical trial subjects.. NAB MAB Antibody Screening Bart Haynes Prophylactic neutralizing Ab CAVD 471 is an antibody screening study to… Read more

Written by CAVD DataSpace Team on January 8, 2019

Tags: data, updates - Category: updates


Pharmacokinetic data is coming soon!

In response to the growing number of studies evaluating the administration of monoclonal antibodies as part of a candidate prevention or treatment regimen, the DataSpace team will be incorporating pharmacokinetic (PK) data into the DataSpace. We're working with the VISC statisticians to develop the dataset format and plots for the new PK BAMA (Luminex) and PK NAb (neutralizing antibody) data. If you have experience with mAb infusion studies and PK data, we'd love to… Read more

Written by CAVD DataSpace Team on December 3, 2018

Tags: collaboration, data, features, updates - Category: announcements, updates


HVTN joins the DataSpace

We are excited to announce that the HIV Vaccine Trials Network (HVTN) has joined the CAVD DataSpace as a contributing network! To further enrich this shared resource, the HVTN is contributing study information and data from HVTN studies — adding to the over 250 studies conducted under the Collaboration for AIDS Vaccine Discovery (CAVD). We're just getting started putting in the HVTN study pages and processing data for a few studies. Here's what you'll see in the DataSpace… Read more

Written by CAVD DataSpace Team on November 2, 2018

Tags: collaboration, data, updates - Category: announcements, updates


Going to HIVR4P 2018?

VISC Statistician, Bryan Mayer, will be presenting an abstract at the upcoming HIVR4P 2018 meeting this week in Madrid, Spain. His poster, "The CAVD DataSpace data sharing and discovery tool facilitates exploration of HIV immunological data from pre-clinical and clinical HIV vaccine studies", highlights key features and several use cases utilizing data from the DataSpace including: Stop by and check it out! HIV Research for Prevention 2018 (HIVR4P 2018) is the… Read more

Written by CAVD DataSpace Team on October 21, 2018

Tags: data, features, conferences - Category: announcements, case-studies


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New Features in DataSpaceR New mAb magnitude-breadth reports New data uploads - November 2020 Publication data now available! New data uploads - June 2020 Specimen repository links

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