Data
Monoclonal antibody data now available!
We've standardized and compiled neutralizing antibody data across monoclonal antibody characterization studies - about 25 studies so far. Using the new mAb interface in DataSpace, you'll be able to: We're continuing to refine and add to this new feature. Here are a few of the things we're working on: This is a work in progress, so send us your feedback. Just click the Give Feedback button at the top of the page or email us at [email protected]. The working… Read more
New data uploads - June 2018
Data has been uploaded for 3 animal studies including: Click on the study page links below for Protocol Team reports, data summaries, and more details about the studies. Name & Description Data Added Type PI Strategy CAVD 443 is a preclinical rabbit study comparing Vesicular Stomatitis Virus (VSV) vector, DNA, and protein regimens with and without adjuvant NAB Pre-Clinical NHP Parks Combo: DNA, protein & vector vaccines CAVD 487 (MU11) is a preclinical mouse study to… Read more
Data export improvements
We've updated some of the Export features in the Data Grid to make it more efficient to export the data out of DataSpace and explore in your own tools. Here's a summary of what's changed: As a reminder, your workbook or zip files contain additional metadata and information about the studies and data you've exported, including: Read more
Durability analysis for NYVAC challenge study timing
VISC statistician, Bryan Mayer, used data from 4 NHP studies testing NYVAC products (CAVD 259, CAVD 277, CAVD 281, and CAVD 434) to inform the design of an upcoming challenge study. Data on the duration of immune responses from the Binding Antibody Multiplex Assay (BAMA), Intracellular Cytokine Staining (ICS), and Neutralizing Antibody (nAb) TZM-bl assays were explored to help define a timeframe for challenge administration during which responses are still… Read more
MAb characterization data is coming soon!
We're organizing a working group to provide feedback and guidance for incorporation of neutralizing antibody (nAb) data from monoclonal antibody (mAb) screening and characterization studies. The group will review the planned implementation in DataSpace and discuss topics such as: If you have experience (or an interest) in mAb nAb data and would like to participate in the working group, contact [email protected]. Read more
New data uploads - November 2017
Data has been uploaded for 3 Ph I/II clinical trials, 7 NHP studies, and 3 other animal studies including: Click on the study page links below for Protocol Team reports, data summaries, and more details about the studies. Name & Description Data Added Type PI Strategy CAVD 256 (EV03/ANRSVAC20) is Phase I/II study to compare the immunogenicity and safety of 3 DNA-C prime followed by 1 NYVAC-C boost to 2 DNA-C prime followed by 2 NYVAC-C boost BAMA Phase I/II Pantaleo Combo: DNA… Read more
Sample size calculation for CAVD 641
Here, we illustrate a sample size calculation using data from the CAVD DataSpace. In this study, our objective was to estimate sample size for a SOSIPv4.1 trimer vaccine study, CAVD 641, comparing the following adjuvants: Alum-3M052, administered via subcutaneous and intramuscular routes, versus GLA-LSQ administered via the intramuscular route. The outcome of interest was viral ID50 neutralization titer measured using the TZM-bl neutralization assay. There are… Read more
Pantaleo CAVD 434/AUP 567 publication and data
CAVD 434/AUP 567 study results were published in the May 2017 issue of the Journal of Virology. Zurawski G, Shen X, Zurawski S, Tomaras GD, Montefiori DC, Roederer M, Ferrari G, Lacabaratz C, Klucar P, Wang Z, Foulds KE, Kao SF, Yu X, Sato A, Yates NL, LaBranche C, Stanfield-Oakley S, Kibler K, Jacobs B, Salazar A, Self S, Fulp W, Gottardo R, Galmin L, Weiss D, Cristillo A, Pantaleo G, Levy Y. Superiority in Rhesus Macaques of Targeting HIV-1 Env gp140 to CD40 versus LOX-1 in… Read more
New data uploads - September 2017
Data has been uploaded for 7 more NHP studies, including: Click on the study page links below for Protocol Team reports, data summaries, and more details about the studies. Name & Description Data Added Type PI Strategy CAVD 281 (AUP 513) is a non-human primate study comparing NYVAC/ALVAC prime/boost regimens BAMA, NAB, ICS Pre-Clinical NHP Pantaleo Combo: Protein & vector vaccines CAVD 355 (CAVIMC-045) is a non-human primate study of protein and adjuvant regimens BAMA… Read more