Features
New mAb magnitude-breadth reports
Over the last year, we've been working with investigators and developers to redesign the data visualizations for monoclonal antibody data in the DataSpace. We've added a new magnitude-breadth curve visualization and improved the functionality of existing reports by offering more interactivity, and increasing the number of mAb-virus combinations and neutralization curves per plot. All plotting is now performed using JavaScript and the D3 JavaScript library… Read more
Publication data now available!
DataSpace now provides analysis datasets on the publication pages in Learn. The Learn section offers detailed information and metadata regarding data found in DataSpace. The Publications section in Learn is a compilation of CAVD and HVTN manuscripts (plus a few other publications for related trials like RV144). Each publication has its own publication page. The data used for these publications can now be posted to and downloaded from the publication pages. In… Read more
Specimen repository links
The HVTN and several other clinical trial networks have collaborated on a shared specimen repository tracking system in order to make the larger body of specimens collected for HIV research available to investigators. The specimens stored at the repositories were initially collected for specific studies that have concluded, have been approved for use by network leadership and are now available to investigators conducting new research. Links to the specimen… Read more
Virus metadata updates
We've updated the Learn about - Assay pages for the neutralizing antibody assays (NAb and NAb MAb) to add more metadata about viruses tested in CAVD and HVTN studies. Viruses listed on the Antigens tab are displayed with a standardized full name and other names used for the virus in publications and databases. The full name includes the virus backbone in brackets, followed by the host cell associated with the virus. The full name will also include the virus type in… Read more
What's in store for the DataSpace
Here are some of the new features you'll see in 2020: And of course, we'll also be loading more CAVD and HVTN study data, including ADCC data integrated across studies. Read more
More assay data now available!
There have been over 50 different assays performed in CAVD and HVTN studies. Currently, the DataSpace provides standardized assay data, integrated across studies, for the most commonly performed assays, i.e. BAMA, ICS, NAb, PK MAb, and ELISpot. In order to provide data for additional assays that have not yet been standardized, or are not able to be standardized, we have upgraded the DataSpace to enable us to post individual, study-specific datasets to the study pages.… Read more
PK mAb data now available!
The CAVD and HVTN have seen an increased emphasis on passive immunization studies where participants receive a monoclonal antibody (mAb) as part of a prophylactic or treatment regimen. The PK data from these studies is important for evaluating and further characterizing those mAbs known to be broadly neutralizing (bNAbs), determining the appropriate dose levels required to maintain optimal concentration levels of mAbs in the blood, and identifying potential… Read more
Finding publications just got easier!
We've added a new feature that gives members a quick and easy way to search for publications. This new Publications section in Learn is a compilation of research conducted under the Collaboration for AIDS Vaccine Discovery (CAVD) and HIV Vaccine Trials Network (HVTN). Use the search box or filters to find publications of interest. Search by: Filter or sort column headers: Click on a publication to get more details, including a full list of authors, a link to the publication… Read more
Pharmacokinetic data is coming soon!
In response to the growing number of studies evaluating the administration of monoclonal antibodies as part of a candidate prevention or treatment regimen, the DataSpace team will be incorporating pharmacokinetic (PK) data into the DataSpace. We're working with the VISC statisticians to develop the dataset format and plots for the new PK BAMA (Luminex) and PK NAb (neutralizing antibody) data. If you have experience with mAb infusion studies and PK data, we'd love to… Read more
Going to HIVR4P 2018?
VISC Statistician, Bryan Mayer, will be presenting an abstract at the upcoming HIVR4P 2018 meeting this week in Madrid, Spain. His poster, "The CAVD DataSpace data sharing and discovery tool facilitates exploration of HIV immunological data from pre-clinical and clinical HIV vaccine studies", highlights key features and several use cases utilizing data from the DataSpace including: Stop by and check it out! HIV Research for Prevention 2018 (HIVR4P 2018) is the… Read more
Monoclonal antibody data now available!
We've standardized and compiled neutralizing antibody data across monoclonal antibody characterization studies - about 25 studies so far. Using the new mAb interface in DataSpace, you'll be able to: We're continuing to refine and add to this new feature. Here are a few of the things we're working on: This is a work in progress, so send us your feedback. Just click the Give Feedback button at the top of the page or email us at [email protected]. The working… Read more
Data export improvements
We've updated some of the Export features in the Data Grid to make it more efficient to export the data out of DataSpace and explore in your own tools. Here's a summary of what's changed: As a reminder, your workbook or zip files contain additional metadata and information about the studies and data you've exported, including: Read more