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PK mAb data now available!
The CAVD and HVTN have seen an increased emphasis on passive immunization studies where participants receive a monoclonal antibody (mAb) as part of a prophylactic or treatment regimen. The PK data from these studies is important for evaluating and further characterizing those mAbs known to be broadly neutralizing (bNAbs), determining the appropriate dose levels required to maintain optimal concentration levels of mAbs in the blood, and identifying potential… Read more
New data uploads - May 2019
Data has been uploaded for 5 studies including: Click on the study page links below for Protocol Team reports, data summaries, and more details about the studies. Name & Description Data Added Type PI Strategy HVTN 097 is a Phase Ib clinical trial to evaluate the safety and immunogenicity of prime/boost regimens using combinations of ALVAC-HIV (vCP1521), AIDSVAX B/E, and bivalent subtype C gp120/MF59. BAMA, ICS, NAB Phase Ib Glenda Gray Combo: DNA, protein & vector… Read more
Finding publications just got easier!
We've added a new feature that gives members a quick and easy way to search for publications. This new Publications section in Learn is a compilation of research conducted under the Collaboration for AIDS Vaccine Discovery (CAVD) and HIV Vaccine Trials Network (HVTN). Use the search box or filters to find publications of interest. Search by: Filter or sort column headers: Click on a publication to get more details, including a full list of authors, a link to the publication… Read more
New data uploads - January 2019
Data has been uploaded for 3 studies including: Click on the study page links below for Protocol Team reports, data summaries, and more details about the studies. Name & Description Data Added Type PI Strategy CAVD 426 is an antibody screening study to isolate and characterize monoclonal antibodies from RV144, RV305, and RV306 human clinical trial subjects.. NAB MAB Antibody Screening Bart Haynes Prophylactic neutralizing Ab CAVD 471 is an antibody screening study to… Read more
Pharmacokinetic data is coming soon!
In response to the growing number of studies evaluating the administration of monoclonal antibodies as part of a candidate prevention or treatment regimen, the DataSpace team will be incorporating pharmacokinetic (PK) data into the DataSpace. We're working with the VISC statisticians to develop the dataset format and plots for the new PK BAMA (Luminex) and PK NAb (neutralizing antibody) data. If you have experience with mAb infusion studies and PK data, we'd love to… Read more
New data uploads - December 2018
Data has been uploaded for 3 studies including: Click on the study page links below for Protocol Team reports, data summaries, and more details about the studies. Name & Description Data Added Type PI Strategy CAVD 353 is an immunogenicity study to evaluate the neutralization activity of the monoclonal antibody, Ibalizumab, and Ibalizumab variants. NAB MAB Antibody Screening David Ho Prophylactic neutralizing Ab CAVD 425 is an immunogenicity study to evaluate the… Read more
Going to the CAVD Annual Meeting?
We'll be at the CAVD Annual Meeting in Seattle: Stop by our demo station on the lower level. New monoclonal antibody data and HVTN studies. Come see what's new! Read more
HVTN joins the DataSpace
We are excited to announce that the HIV Vaccine Trials Network (HVTN) has joined the CAVD DataSpace as a contributing network! To further enrich this shared resource, the HVTN is contributing study information and data from HVTN studies — adding to the over 250 studies conducted under the Collaboration for AIDS Vaccine Discovery (CAVD). We're just getting started putting in the HVTN study pages and processing data for a few studies. Here's what you'll see in the DataSpace… Read more
Going to the HVTN Investigators Meeting in Seattle?
We'll be at two HVTN venues in Seattle next week: Stop by our demonstration table located in the Leonessa Foyer of the Grand Hyatt. Read more
More mAb data improvements
We're continuing to refine and add to the new mAb data feature. Here are a few of the things we've been working on: Figure 1: New mAb section in Learn Go to Learn > MAbs. Select a mAb or mAb mixture to find more details. Figure 2: New pages for each mAb in Learn Find additional details about the mAbs, including what studies tested the mAb and whether there is data available for that mAb in the DataSpace. The mAb pages also include a link to the Los Alamos National Lab (LANL) Antibody… Read more
Going to HIVR4P 2018?
VISC Statistician, Bryan Mayer, will be presenting an abstract at the upcoming HIVR4P 2018 meeting this week in Madrid, Spain. His poster, "The CAVD DataSpace data sharing and discovery tool facilitates exploration of HIV immunological data from pre-clinical and clinical HIV vaccine studies", highlights key features and several use cases utilizing data from the DataSpace including: Stop by and check it out! HIV Research for Prevention 2018 (HIVR4P 2018) is the… Read more
Monoclonal antibody data now available!
We've standardized and compiled neutralizing antibody data across monoclonal antibody characterization studies - about 25 studies so far. Using the new mAb interface in DataSpace, you'll be able to: We're continuing to refine and add to this new feature. Here are a few of the things we're working on: This is a work in progress, so send us your feedback. Just click the Give Feedback button at the top of the page or email us at [email protected]. The working… Read more