Updates
Finding publications just got easier!
We've added a new feature that gives members a quick and easy way to search for publications. This new Publications section in Learn is a compilation of research conducted under the Collaboration for AIDS Vaccine Discovery (CAVD) and HIV Vaccine Trials Network (HVTN). Use the search box or filters to find publications of interest. Search by: Filter or sort column headers: Click on a publication to get more details, including a full list of authors, a link to the publication… Read more
New data uploads - January 2019
Data has been uploaded for 3 studies including: Click on the study page links below for Protocol Team reports, data summaries, and more details about the studies. Name & Description Data Added Type PI Strategy CAVD 426 is an antibody screening study to isolate and characterize monoclonal antibodies from RV144, RV305, and RV306 human clinical trial subjects.. NAB MAB Antibody Screening Bart Haynes Prophylactic neutralizing Ab CAVD 471 is an antibody screening study to… Read more
Pharmacokinetic data is coming soon!
In response to the growing number of studies evaluating the administration of monoclonal antibodies as part of a candidate prevention or treatment regimen, the DataSpace team will be incorporating pharmacokinetic (PK) data into the DataSpace. We're working with the VISC statisticians to develop the dataset format and plots for the new PK BAMA (Luminex) and PK NAb (neutralizing antibody) data. If you have experience with mAb infusion studies and PK data, we'd love to… Read more
New data uploads - December 2018
Data has been uploaded for 3 studies including: Click on the study page links below for Protocol Team reports, data summaries, and more details about the studies. Name & Description Data Added Type PI Strategy CAVD 353 is an immunogenicity study to evaluate the neutralization activity of the monoclonal antibody, Ibalizumab, and Ibalizumab variants. NAB MAB Antibody Screening David Ho Prophylactic neutralizing Ab CAVD 425 is an immunogenicity study to evaluate the… Read more
HVTN joins the DataSpace
We are excited to announce that the HIV Vaccine Trials Network (HVTN) has joined the CAVD DataSpace as a contributing network! To further enrich this shared resource, the HVTN is contributing study information and data from HVTN studies — adding to the over 250 studies conducted under the Collaboration for AIDS Vaccine Discovery (CAVD). We're just getting started putting in the HVTN study pages and processing data for a few studies. Here's what you'll see in the DataSpace… Read more
More mAb data improvements
We're continuing to refine and add to the new mAb data feature. Here are a few of the things we've been working on: Figure 1: New mAb section in Learn Go to Learn > MAbs. Select a mAb or mAb mixture to find more details. Figure 2: New pages for each mAb in Learn Find additional details about the mAbs, including what studies tested the mAb and whether there is data available for that mAb in the DataSpace. The mAb pages also include a link to the Los Alamos National Lab (LANL) Antibody… Read more
Monoclonal antibody data now available!
We've standardized and compiled neutralizing antibody data across monoclonal antibody characterization studies - about 25 studies so far. Using the new mAb interface in DataSpace, you'll be able to: We're continuing to refine and add to this new feature. Here are a few of the things we're working on: This is a work in progress, so send us your feedback. Just click the Give Feedback button at the top of the page or email us at [email protected]. The working… Read more
An Open DataSpace
When we launched the CAVD DataSpace in December 2015, DataSpace membership included active and former members of the CAVD. In the fall of 2017, we invited members from HIV vaccine networks beyond the CAVD to join the DataSpace. Since then, we've been reaching out to networks to identify target members who'd benefit the most from accessing the DataSpace, specifically, investigators, junior investigators, staff scientists, and post docs involved in concept… Read more
New data uploads - June 2018
Data has been uploaded for 3 animal studies including: Click on the study page links below for Protocol Team reports, data summaries, and more details about the studies. Name & Description Data Added Type PI Strategy CAVD 443 is a preclinical rabbit study comparing Vesicular Stomatitis Virus (VSV) vector, DNA, and protein regimens with and without adjuvant NAB Pre-Clinical NHP Parks Combo: DNA, protein & vector vaccines CAVD 487 (MU11) is a preclinical mouse study to… Read more
Data export improvements
We've updated some of the Export features in the Data Grid to make it more efficient to export the data out of DataSpace and explore in your own tools. Here's a summary of what's changed: As a reminder, your workbook or zip files contain additional metadata and information about the studies and data you've exported, including: Read more
MAb data? You betcha!
The DataSpace team has been busy processing the neutralizing antibody data from monoclonal antibody (mAb) screening and characterization studies. We aim to have mAb data available in DataSpace for exploration by late summer/early fall. Here's a mock-up of the new mAb section we are developing for the DataSpace. Using this summary view, you'll be able to: If you have experience (and/or an interest) in mAb nAb data and would like to participate in the working group,… Read more
MAb characterization data is coming soon!
We're organizing a working group to provide feedback and guidance for incorporation of neutralizing antibody (nAb) data from monoclonal antibody (mAb) screening and characterization studies. The group will review the planned implementation in DataSpace and discuss topics such as: If you have experience (or an interest) in mAb nAb data and would like to participate in the working group, contact [email protected]. Read more